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clawbio

Name: clawbio
Author: wenliangz

By wenliangz

Bioinformatics-native AI agent skill library — pharmacogenomics, ancestry, scRNA-seq, metagenomics, variant annotation, genome comparison, and more. 24 skills with deterministic Python execution, reproducibility bundles, and local-first privacy.

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What's Inside

Slash Commands4

analyse

/analyse

Run a ClawBio bioinformatics analysis on user-provided genetic data

list-skills

/list-skills

List all available ClawBio bioinformatics skills with their status and capabilities

New Skill Builder

/new-skill

Build a new ClawBio skill from the official template with full conformance enforcement.

run-demo

/run-demo

Run a ClawBio skill demo with built-in sample data

Skills45

cell-detection

/cell-detection

Cell segmentation in fluorescence microscopy images. Supports Cellpose/cpsam (Cellpose 4.0) with additional backends planned. Produces segmentation masks, per-cell morphology metrics (area, diameter, centroid, eccentricity), overlay figures, and a report.md.

bioconductor-bridge

/bioconductor-bridge

Bioconductor package discovery, workflow recommendation, setup inspection, and starter code generation grounded in official Bioconductor containers and BiocManager.

bigquery-public

/bigquery-public

Run read-only SQL against BigQuery public datasets with local result capture, cost safeguards, and reproducibility outputs.

bio-orchestrator

/bio-orchestrator

Meta-agent that routes bioinformatics requests to specialised sub-skills. Handles file type detection, analysis planning, report generation, and reproducibility export.

🦖 Ancestry Decomposition PCA

/claw-ancestry-pca

Place your study cohort in global genetic context by computing a joint PCA against the Simons Genome Diversity Project (SGDP) — 345 samples from 164 populations spanning every inhabited continent.

The plugin manifest points to a different repository than the source indexed by ClaudePluginHub.

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Version0.3.0

LanguageHTML

Stars0

MaintenancePoor

LicenseMIT

Last CommitApr 5, 2026

AddedJul 13, 2026

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README

ClawBio

The first bioinformatics-native AI agent skill library.
Built on OpenClaw (180k+ GitHub stars). Local-first. Privacy-focused. Reproducible.

AI Agents for Health: ClawBio Hackathon
Thu 23 April 2026, 12:00-19:00 · University of Westminster, Cavendish Campus, London
Register free on Luma

ClawBio GWAS Lookup demo — querying 9 genomic databases from the terminal

What ClawBio Does Today

44 executable skills + 8,000 Galaxy tools + 687 tests + benchmark validation. Local-first. No cloud. No guessing.

v0.5.0 released (4 Apr 2026): Validation and Benchmark Infrastructure. AD ground truth benchmark, mock API server for offline testing, swappable fine-mapping pipeline (SuSiE vs ABF), 74 benchmark tests, red/green TDD mandate. Release notes. DOI: 10.5281/zenodo.19420648.

Snap a photo of a medication in Telegram. ClawBio identifies the drug from the packaging, queries your pharmacogenomic profile from your own genome, and returns a personalised dosage card — on your machine, in seconds:

Warfarin 2mg medication packaging — ClawBio identifies the drug from a photo and returns a personalised pharmacogenomic report

Warfarin | CYP2C9 *1/*2 Intermediate · VKORC1 High Sensitivity AVOID — DO NOT USE · Standard dose causes over-anticoagulation in this genotype.

Or take any genetic variant (identified by its rsID — a unique label like rs9923231) and search nine genomic databases at once to find every known disease association, tissue-specific effect, and population frequency. Or estimate your genetic predisposition to conditions like type 2 diabetes by combining thousands of small-effect variants into a single polygenic risk score. Or explore the UK Biobank — a half-million-person research dataset — by asking in plain English what fields measure blood pressure, grip strength, or depression, and get back the exact field IDs, descriptions, and linked publications you need.

Every result ships with a reproducibility bundle: commands.sh, environment.yml, and SHA-256 checksums. A reviewer can reproduce your Figure 3 in 30 seconds without emailing you.

Reference Genome

ClawBio's demo data is built on a real, fully open human genome: the Corpasome. The 23andMe SNP chip (~600K variants) has been available since launch. Now, the project also ships subsets from a 30x Illumina whole-genome sequence (GRCh37), covering ~4M SNPs, ~600K indels, and structural variants (DEL, DUP, INV, BND, INS, CNVs). All data comes from a single individual (Manuel Corpas), licensed CC0, and published on Zenodo (doi:10.5281/zenodo.19297389). This dataset is provided for research and educational purposes only.

See docs/reference-genome.md for use cases, subsets, and citation details.

Validation & Benchmarking

View full README on GitHub

clawbio

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